Johnston P G, Ruscetti F W, Connaghan D G, Sullivan F J, Longo D L
Medicine Branch, N.C.I., N.I.H., Bethesda, MD 20892.
Am J Hematol. 1991 Sep;38(1):54-60. doi: 10.1002/ajh.2830380109.
This report describes a patient with lymphocyte depleted Hodgkin's disease who presented with bone marrow aplasia. The aplastic marrow reverted to normal after initiation of MOPP chemotherapy; however, 4 months after completion of therapy, bone marrow aplasia recurred in the absence of recurrent Hodgkin's disease. The patient remains free of Hodgkin's disease 34 months after completion of chemotherapy. Bone marrow abnormalities in Hodgkin's disease are reviewed and the current understanding of the pathological mechanisms leading to aplastic anemia is discussed.
本报告描述了一名患有淋巴细胞消减型霍奇金病且伴有骨髓再生障碍的患者。在开始MOPP化疗后，再生障碍性骨髓恢复正常；然而，在治疗结束4个月后，在无复发性霍奇金病的情况下骨髓再生障碍复发。化疗结束34个月后，该患者仍未患霍奇金病。本文回顾了霍奇金病中的骨髓异常情况，并讨论了目前对导致再生障碍性贫血病理机制的理解。
