Burm J P
College of Nursing, Chosun University, 501-140, Kwangju, Korea.
Arch Pharm Res. 1997 Apr;20(2):171-5. doi: 10.1007/BF02974005.
The stability of ondansetron and fluconazole in 5% dextrose injection and normal saline during simulated Y-site injection at room temperature was studied. Ondansetron 0.03, 0.1 and 0.3 mg/ml were admixed 1ratio1 with fluconazole 2 mg/ml. The solutions were stored at room temperature and samples were retrieved at time 0, 1, 2, 4 and 12 hr for immediate assay. At the time of the assay and before any dilution, each sample was visually inspected for clarity, color, precipitation, and the pH was determined. Drug concentrations were measured by a stability-indicating high performance liquid chromatograph. Ondansetron 0.03, 0.1 and 0.3 mg/ml were stable when mixed with concentration of fluconazole 2 mg/ml. There were no change in clarity and color and no precipitates in any admixture for 12 hr of inspection. The pH measurements did not have a particular trend in any direction over time.
研究了在室温下模拟Y型静脉注射时，昂丹司琼和氟康唑在5%葡萄糖注射液和生理盐水中的稳定性。将0.03、0.1和0.3mg/ml的昂丹司琼与2mg/ml的氟康唑按1:1混合。溶液在室温下储存，并在0、1、2、4和12小时取样立即测定。在测定时且在任何稀释之前，对每个样品进行外观检查，观察其澄清度、颜色、沉淀情况，并测定pH值。通过稳定性指示高效液相色谱仪测量药物浓度。0.03、0.1和0.3mg/ml的昂丹司琼与2mg/ml的氟康唑混合时是稳定的。在12小时的检查中，任何混合物的澄清度和颜色均无变化，也无沉淀。随着时间的推移，pH测量值没有特定的变化趋势。
