Fukagawa Hiroshi, Hashiguchi Mitsuko, Ayabe Yuko, Ando Taiki, Nakamura Kumi
Department of Anesthesia, Kyoto City Hospital, Kyoto 604-8845.
Masui. 2008 Oct;57(10):1241-4.
A 55-year-old man was scheduled for resection of an adrenal tumor under the diagnosis of a non-functioning adrenal tumor. He was admitted for unstable angina 58 days preoperatively, and on the second hospital day, he had an episode of ventricular tachycardia for 20 seconds following epigastric pain. Abdominal computed tomography scans revealed a retroperitoneal abscess, which was subsequently drained effectively, and a right adrenal tumor. Because of the almost normal plasma catecholamine concentration, the tumor was considered a nonfunctioning tumor. However, when the surgeon manipulated the tumor during the operation, the patient's blood pressure increased suddenly to 240/120 mmHg. The hypertensive crisis was managed with nicardipine and phentolamine. After resection of the tumor, his blood pressure decreased to 80/40 mmHg, and the patient was treated with ephedrine, phenylephrine, and noradrenaline. After surgery, the tumor was confirmed histopathologically as a pheochromocytoma. The management of patients with a hypertensive crisis under suspicion of pheochromocytoma is discussed.
一名55岁男性因诊断为无功能肾上腺肿瘤而计划行肾上腺肿瘤切除术。他在术前58天因不稳定型心绞痛入院,入院第二天,上腹部疼痛后出现了一次持续20秒的室性心动过速。腹部计算机断层扫描显示腹膜后脓肿,随后脓肿得到有效引流,同时发现右肾上腺肿瘤。由于血浆儿茶酚胺浓度几乎正常,该肿瘤被认为是无功能肿瘤。然而,手术过程中外科医生操作肿瘤时,患者血压突然升至240/120 mmHg。高血压危象通过尼卡地平和酚妥拉明进行处理。肿瘤切除后,患者血压降至80/40 mmHg,随后使用麻黄碱、去氧肾上腺素和去甲肾上腺素进行治疗。术后,肿瘤经组织病理学确诊为嗜铬细胞瘤。本文讨论了疑似嗜铬细胞瘤患者高血压危象的处理。