Shaw B E
Anthony Nolan Research Institute, Royal Free Hospital, Hampstead, UK.
Int J Immunogenet. 2008 Aug;35(4-5):367-74. doi: 10.1111/j.1744-313X.2008.00793.x.
Haematopoietic stem cell transplantation (HSCT), using unrelated donors (UD), is now a common modality of treatment for individuals with a variety of different diseases. HLA matching has been shown to have a significant impact on patient outcome. This study includes 423 unrelated UK patient/donor pairs. The patients and donors were typed at high resolution for HLA-A, -B, -C, -DRB1, -DQB1, -DPB1. The degree and type of HLA mismatch was found to be a significant factor affecting outcome. The matching status for DPB1, both at an allele and epitope level, significantly affected transplant complications. The findings of this study have made it possible to offer advice concerning the choice of the most appropriate unrelated donor to select in order to achieve the best patient outcomes.
使用无关供体（UD）的造血干细胞移植（HSCT）现在是治疗患有各种不同疾病个体的常见治疗方式。已证明HLA配型对患者预后有重大影响。本研究纳入了423对英国无关患者/供体。对患者和供体进行了HLA-A、-B、-C、-DRB1、-DQB1、-DPB1的高分辨率分型。发现HLA错配的程度和类型是影响预后的重要因素。DPB1在等位基因和表位水平的匹配状态均显著影响移植并发症。本研究结果使得能够就选择最合适的无关供体以实现最佳患者预后提供建议。
