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捷克患者中白细胞介素-6基因多态性与异基因造血干细胞移植结局的关联

Association of IL-6 gene polymorphism with the outcome of allogeneic haematopoietic stem cell transplantation in Czech patients.

作者信息

Ambruzova Z, Mrazek F, Raida L, Faber E, Onderkova J, Kriegova E, Indrak K, Petrek M

机构信息

Department of Immunology, Tissue Typing Laboratory, Palacky University Olomouc, Czech Republic.

出版信息

Int J Immunogenet. 2008 Aug;35(4-5):401-3. doi: 10.1111/j.1744-313X.2008.00798.x.

DOI:10.1111/j.1744-313X.2008.00798.x
PMID:18976446
Abstract

Interleukin-6 (IL-6) is an important pro-inflammatory mediator implicated in immune-mediated complications of allogeneic haematopoietic stem cell transplantation (aHSCT). In accord with previous reports, this preliminary study on 56 donor-recipient pairs revealed IL-6-174 single nucleotide polymorphisms as a risk factor for the development of acute graft-versus-host disease and decreased survival after aHSCT.

摘要

白细胞介素-6（IL-6）是一种重要的促炎介质，与异基因造血干细胞移植（aHSCT）的免疫介导并发症有关。与之前的报道一致，这项对56对供体-受体的初步研究表明，IL-6 -174单核苷酸多态性是急性移植物抗宿主病发生和aHSCT后生存率降低的一个风险因素。

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