Klonizakis Markos, Tew Garry, Michaels Jonathan, Saxton John
The Sheffield Vascular Institute, Northern General Hospital, Herries Road, Sheffield, S5 7AU, UK.
Microvasc Res. 2009 Mar;77(2):158-62. doi: 10.1016/j.mvr.2008.09.009. Epub 2008 Oct 11.
Evidence exists that cutaneous microvascular endothelial dysfunction persists in patients following varicose vein surgery. This study compared cutaneous microvascular function between post-surgical varicose vein patients and healthy controls and investigated whether any impairment of function can be attenuated by acute lower-limb exercise. Cutaneous flux responses of the gaiter area were measured in supine and standing positions before and after a 25-min walk using laser Doppler fluximetry and incremental-dose administration of acetylcholine (ACh) and sodium nitroprusside (SNP). The pre-exercise peak responses to ACh (standing) were lower in patients than controls (48+/-11 vs. 96+/-28 PU; P=0.032), whereas treadmill exercise abolished this difference (P=0.819). In contrast, the pre-exercise responses to SNP (standing) appeared higher in patients than controls (3 mC responses: 24+/-4 vs. 10+/-2 PU, respectively; P=0.023), with no effect of acute exercise (P>0.05). These findings suggest that acute treadmill exercise augments microvascular endothelial function in post-surgical varicose vein patients to levels observed in age-matched controls.
有证据表明，静脉曲张手术后患者的皮肤微血管内皮功能障碍持续存在。本研究比较了静脉曲张手术患者与健康对照者的皮肤微血管功能，并研究了急性下肢运动是否可以减轻任何功能损害。使用激光多普勒血流仪以及递增剂量给予乙酰胆碱（ACh）和硝普钠（SNP），在25分钟步行前后的仰卧位和站立位测量小腿肚区域的皮肤血流反应。患者运动前对ACh（站立位）的峰值反应低于对照组（48±11 vs. 96±28 PU；P=0.032），而跑步机运动消除了这种差异（P=0.819）。相反，患者运动前对SNP（站立位）的反应似乎高于对照组（3 mC反应：分别为24±4 vs. 10±2 PU；P=0.023），急性运动对此无影响（P>0.05）。这些发现表明，急性跑步机运动可使静脉曲张手术患者的微血管内皮功能增强至年龄匹配对照组的水平。
