Unno Keiko, Yamamoto Hiroyuki, Maeda Ken-Ichi, Takabayashi Fumiyo, Yoshida Hirotoshi, Kikunaga Naomi, Takamori Nina, Asahina Shunsuke, Iguchi Kazuaki, Sayama Kazutoshi, Hoshino Minoru
Laboratory of Bioorganic Chemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan.
Physiol Behav. 2009 Feb 16;96(2):262-9. doi: 10.1016/j.physbeh.2008.10.009. Epub 2008 Oct 17.
To investigate the effect of a high-fat diet on brain and pancreas functions, we used SAMP10 mice that have characteristics of brain atrophy and cognitive dysfunction with aging. Simultaneously, we investigated the effect of green tea catechin consumption on high-fat diet feeding, because green tea catechin has been reported to improve brain atrophy, brain dysfunction and obesity. The body weight of mice fed a high-fat diet from 2 to 12 months was higher than that of the control, although the calorie intake was not. The high-fat diet also increased insulin secretion; however, the hypersecretion of insulin and obesity were suppressed when mice were fed a high-fat diet with green tea catechin and caffeine. Furthermore, brain atrophy was suppressed and the working memory, tested using Y-maze, improved in mice fed a high-fat diet containing green tea catechin and caffeine. The secretion of insulin might affect both obesity and brain function. A strong correlation was found between working memory and insulin release in mice fed a high-fat diet with green tea catechin and/or caffeine. The results indicate the protective effect of green tea catechin and caffeine on the functions of brain and pancreas in mice fed a high-fat diet.
为研究高脂饮食对大脑和胰腺功能的影响，我们使用了具有随着年龄增长而出现脑萎缩和认知功能障碍特征的SAMP10小鼠。同时，我们研究了食用绿茶儿茶素对高脂饮食喂养的影响，因为据报道绿茶儿茶素可改善脑萎缩、脑功能障碍和肥胖。从2个月到12个月喂食高脂饮食的小鼠体重高于对照组，尽管卡路里摄入量并无差异。高脂饮食还增加了胰岛素分泌；然而，当给小鼠喂食含有绿茶儿茶素和咖啡因的高脂饮食时，胰岛素的过度分泌和肥胖受到了抑制。此外，在喂食含有绿茶儿茶素和咖啡因的高脂饮食的小鼠中，脑萎缩受到抑制，并且使用Y迷宫测试的工作记忆得到改善。胰岛素的分泌可能会影响肥胖和脑功能。在喂食含有绿茶儿茶素和/或咖啡因的高脂饮食的小鼠中，发现工作记忆与胰岛素释放之间存在很强的相关性。结果表明，绿茶儿茶素和咖啡因对喂食高脂饮食的小鼠的大脑和胰腺功能具有保护作用。
