孕激素及复方口服避孕药对腹膜子宫内膜异位症神经纤维的影响。
Effect of progestogens and combined oral contraceptives on nerve fibers in peritoneal endometriosis.
作者信息
Tokushige Natsuko, Markham Robert, Russell Peter, Fraser Ian S
机构信息
Department of Obstetrics and Gynaecology, Queen Elizabeth II Research Institute for Mothers and Infants, and the Department of Pathology, University of Sydney, Sydney, Australia.
Department of Obstetrics and Gynaecology, Queen Elizabeth II Research Institute for Mothers and Infants, and the Department of Pathology, University of Sydney, Sydney, Australia.
出版信息
Fertil Steril. 2009 Oct;92(4):1234-1239. doi: 10.1016/j.fertnstert.2008.07.1774. Epub 2008 Oct 31.
OBJECTIVE
To investigate how progestogens and combined oral contraceptives change nerve fiber density in peritoneal endometriotic lesions and to identify the types of nerve fibers still present during hormone treatment.
DESIGN
Laboratory study using human tissue.
SETTING
University-based laboratory.
PATIENT(S): Hormonally treated and untreated women with endometriosis undergoing laparoscopy, hysteroscopy, and curettage.
INTERVENTION(S): Biopsy samples from peritoneal endometriotic lesions in hormonally treated and untreated women with endometriosis.
MAIN OUTCOME MEASURE(S): Types and density of nerve fibers were immunohistochemically determined in peritoneal endometriotic lesions from hormonally treated and untreated women with endometriosis.
RESULT(S): The nerve fiber density (mean +/- standard deviation/mm(2)) in peritoneal endometriotic lesions from hormone-treated women with endometriosis (10.6 +/- 2.2/mm(2)) was statistically significantly lower than in peritoneal endometriotic lesions from untreated women with endometriosis (16.3 +/-10.0/mm(2)). Nerve growth factor and nerve growth factor receptor p75 expression in peritoneal endometriotic lesions were slightly reduced in hormone-treated women with endometriosis compared with untreated women with endometriosis.
CONCLUSION(S): Progestogens and combined oral contraceptives reduced nerve fiber density and nerve growth factor and nerve growth factor receptor p75 expression in peritoneal endometriotic lesions.
目的
研究孕激素及复方口服避孕药如何改变腹膜子宫内膜异位症病灶中的神经纤维密度，并确定激素治疗期间仍存在的神经纤维类型。
设计
使用人体组织的实验室研究。
地点
大学实验室。
患者
接受激素治疗和未接受激素治疗的子宫内膜异位症女性，她们接受了腹腔镜检查、宫腔镜检查和刮宫术。
干预措施
从接受激素治疗和未接受激素治疗的子宫内膜异位症女性的腹膜子宫内膜异位症病灶中获取活检样本。
主要观察指标
通过免疫组织化学方法测定接受激素治疗和未接受激素治疗的子宫内膜异位症女性腹膜子宫内膜异位症病灶中神经纤维的类型和密度。
结果
接受激素治疗的子宫内膜异位症女性腹膜子宫内膜异位症病灶中的神经纤维密度（平均值±标准差/mm²）为（10.6±2.2/mm²），显著低于未接受激素治疗的子宫内膜异位症女性腹膜子宫内膜异位症病灶中的神经纤维密度（16.3±10.0/mm²）。与未接受激素治疗的子宫内膜异位症女性相比，接受激素治疗的子宫内膜异位症女性腹膜子宫内膜异位症病灶中神经生长因子和神经生长因子受体p75的表达略有降低。
结论
孕激素及复方口服避孕药可降低腹膜子宫内膜异位症病灶中的神经纤维密度以及神经生长因子和神经生长因子受体p75的表达。
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