He Xiao-Li, Wang Yue-Hua, Gao Mei, Li Xiao-Xiu, Zhang Tian-Tai, Du Guan-Hua
National Center for Pharmaceutical Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 1 Xian Nong Tan Street, Beijing 100050, China.
Brain Res. 2009 Jan 16;1249:212-21. doi: 10.1016/j.brainres.2008.10.005. Epub 2008 Oct 18.
This study investigated the effects of baicalein, a natural compound isolated from the root of scutellaria, on cognitive and motor ability impaired by chronic cerebral hypoperfusion in rats, as well as its effects on brain mitochondria. Rats subjected to permanent bilateral common carotid artery occlusion experienced cognitive deficits, oxidative stress and mitochondria dysfunction, which was associated with the elevation of reactive oxygen species level, the decrease of oxidative phosphorylation parameters, the loss of mitochondrial membrane potential, the reduce in Bcl-2/Bax ratio, and the release of cytochrome c. Baicalein alleviated cognitive and motor impairments and decreased mitochondria reactive oxygen species production, in accordance with its improvements on membrane potential level, oxidative phosphorylation process, mitochondrial swelling degree, Bcl-2/Bax ratio and cytochrome c release. These data indicated that baicalein might have therapeutic potential for the treatment of dementia caused by chronic cerebral hypoperfusion, contributed to its protections on brain mitochondrial homeostasis and function.
本研究探讨了从黄芩根中分离出的天然化合物黄芩苷对大鼠慢性脑灌注不足所致认知和运动能力损害的影响及其对脑线粒体的作用。永久性双侧颈总动脉闭塞的大鼠出现认知缺陷、氧化应激和线粒体功能障碍，这与活性氧水平升高、氧化磷酸化参数降低、线粒体膜电位丧失、Bcl-2/Bax比值降低以及细胞色素c释放有关。黄芩苷减轻了认知和运动障碍，减少了线粒体活性氧的产生，这与其对膜电位水平、氧化磷酸化过程、线粒体肿胀程度、Bcl-2/Bax比值和细胞色素c释放的改善一致。这些数据表明，黄芩苷可能对治疗慢性脑灌注不足所致痴呆具有治疗潜力，这得益于其对脑线粒体稳态和功能的保护作用。
