重建MLL-AF4白血病的疾病模型和表观遗传网络。
Reconstructing the disease model and epigenetic networks for MLL-AF4 leukemia.
作者信息
Zeisig Bernd B, Cheung Ngai, Yeung Jenny, So Chi Wai Eric
机构信息
Leukaemogenesis Team, Section of Haemato-Oncology, The Institute of Cancer Research, Sutton, Greater London, UK.
出版信息
Cancer Cell. 2008 Nov 4;14(5):345-7. doi: 10.1016/j.ccr.2008.10.008.
PMID:18977321
Abstract
The lack of a proper animal model has impeded understanding of the molecular mechanism of leukemia associated with the MLL-AF4 fusion. In this issue of Cancer Cell, Krivtsov et al. report a much-improved murine Mll-AF4 model and propose a molecular link with H3K79 methylation mediated by the histone methyltransferase DOT1L.
摘要
缺乏合适的动物模型阻碍了对与MLL-AF4融合相关的白血病分子机制的理解。在本期《癌细胞》杂志中，克里夫佐夫等人报告了一个显著改进的小鼠Mll-AF4模型，并提出了与组蛋白甲基转移酶DOT1L介导的H3K79甲基化的分子联系。
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