Lee Ji-Won, Im Jee-Aee, Park Ki Deok, Lee Hye-Ree, Shim Jae-Yong, Lee Duk-Chul
Department of Family Medicine, Severance Hospital, Yonsei University College of Medicine, Republic of Korea.
Clin Chim Acta. 2009 Feb;400(1-2):30-2. doi: 10.1016/j.cca.2008.10.004. Epub 2008 Oct 17.
Insulin resistance (IR) increases with advancing age, yet the underlying mechanism is not well established. Although adipocytokine retinol binding protein 4 (RBP4) was recently shown to be linked to IR, their relationship remains controversial and relatively little information exists regarding their roles in the elderly subjects. We investigated the association between RBP4 and IR in obese and nonobese elderly subjects.
A total of 111 (68 nonobese and 43 obese) apparently healthy elderly subjects, aged 75.9+/-4.8 y were included. IR was determined by homeostasis model assessment (HOMA-IR). Serum RBP4 was measured by enzyme-linked immunosorbent assay.
In all subjects, RBP4 levels were positively correlated with fasting insulin, HOMA-IR, and triglycerides. However, after subgroup analysis, RBP4 levels were positively correlated with fasting glucose, fasting insulin, and HOMA-IR in the obese group only. In step-wise multiple linear regression analysis, RBP4 was found to be independently associated with triglyceride levels in the nonobese group and independently associated with HOMA-IR in the obese group.
The reason for the differing metabolic role of RBP4 in obese and nonobese elderly subjects remains uncertain, but our findings suggest that RBP4 may be linked to IR and lipid metabolism, at least in the elderly.
胰岛素抵抗（IR）随年龄增长而增加，但其潜在机制尚未完全明确。尽管最近有研究表明脂肪细胞因子视黄醇结合蛋白4（RBP4）与IR有关，但其关系仍存在争议，关于它们在老年受试者中的作用的信息相对较少。我们研究了肥胖和非肥胖老年受试者中RBP4与IR之间的关联。
共纳入111名（68名非肥胖和43名肥胖）年龄为75.9±4.8岁的明显健康的老年受试者。通过稳态模型评估（HOMA-IR）来确定IR。采用酶联免疫吸附测定法测量血清RBP4。
在所有受试者中，RBP4水平与空腹胰岛素、HOMA-IR和甘油三酯呈正相关。然而，亚组分析后发现，仅在肥胖组中，RBP4水平与空腹血糖、空腹胰岛素和HOMA-IR呈正相关。在逐步多元线性回归分析中，发现RBP4在非肥胖组中与甘油三酯水平独立相关，在肥胖组中与HOMA-IR独立相关。
RBP4在肥胖和非肥胖老年受试者中代谢作用不同的原因尚不确定，但我们的研究结果表明，至少在老年人中，RBP4可能与IR和脂质代谢有关。
