Notch-regulated perineurium development from zebrafish spinal cord.

In the developing central nervous system, nerve fascicles are surrounded by a protective sheath known as the perineurium. Perineurium is composed of perineurial cells that have both epithelial and myofibroblastoid properties, including tight and gap junctions and contractility. However, the molecular mechanism that governs perineurial development remains unclear. Here we focused on fabp7a, a brain lipid binding protein that is reportedly crucial for the proper differentiation of radial glial progenitor cells. Our study reveals that fabp7a is expressed in the lateral floor plate cells, and later perineurial glia in the spinal cord of zebrafish embryos. Furthermore, Notch signaling regulated perineurial glia development by maintaining fabp7a-expressing cells, demonstrating a novel mechanism for perineurial development.