Morgaz J, Granados M M, Domínguez J M, Navarrete R, Galán A, Fernández J A, Gómez-Villamandos R J
Department of Animal Medicine and Surgery, Veterinary School of Córdoba, Universtity of Córdoba, Francisco Santisteban Hospital, Campus de Rabanales 14014, Córdoba, Spain.
Res Vet Sci. 2009 Jun;86(3):508-13. doi: 10.1016/j.rvsc.2008.09.005. Epub 2008 Nov 1.
The relationships between bispectral index (BIS), cardiovascular variables and minimum alveolar concentration (MAC) multiples of sevoflurane in puppies were determined. Five puppies were anesthetized with sevoflurane on two occasions. First, the individual sevoflurane MAC values were determined for each puppy. Secondly, dogs were anesthetized with sevoflurane at each of 5 MAC multiples, 0.75, 1, 1.25, 1.5 and 1.75 MAC administered in random order. Hemodynamic parameters and BIS data were collected for 20min. Somatic stimulus was then applied and the same parameters and data were collected for 6min. Correlation between BIS and end tidal sevoflurane and between BIS and hemodynamic parameters were studied. We found positive significant correlation in both cases. BIS is lower in puppies that in adults at the same alveolar anesthetic concentrations and sevoflurane appears to be a safe anesthetic in puppies.
测定了幼犬的脑电双频指数（BIS）、心血管变量与七氟醚最低肺泡有效浓度（MAC）倍数之间的关系。五只幼犬分两次接受七氟醚麻醉。首先，测定每只幼犬的七氟醚个体MAC值。其次，以随机顺序分别用0.75、1、1.25、1.5和1.75倍MAC的七氟醚麻醉犬。收集血流动力学参数和BIS数据20分钟。然后施加躯体刺激，并收集相同参数和数据6分钟。研究了BIS与呼气末七氟醚之间以及BIS与血流动力学参数之间的相关性。我们发现在这两种情况下均存在显著正相关。在相同肺泡麻醉浓度下，幼犬的BIS低于成年犬，并且七氟醚似乎是幼犬的一种安全麻醉剂。
