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[术后病程复杂的心脏手术患者血液中生长激素和胰岛素的浓度]

[The concentrations of somatotropic hormone and insulin in the blood of heart surgery patients with a complicated course of the postoperative period].

作者信息

Kuznetsova B A, Saprygin D B, Kuliev E A, Mikhaĭlova I L, Poplavskaia L M

出版信息

Anesteziol Reanimatol. 1991 May-Jun(3):49-53.

PMID:1897796
Abstract

It has been shown that the course of the early postoperative period in cardiosurgical patients and its outcome is to a great extent related to adequate balance of adaptation hormones, whose levels and changes are determined by the functional state of compensatory-adaptive systems. Patients with favourable outcome of the complicated postoperative period along with synchronous activation of sympathoadrenal system (SAS), hypophyseoadrenal system (HAS) and an elevated somatotropic hormone (STH) level demonstrated adequately high blood insulin content, with the equilibrium in adrenalin/insulin and cortisol/insulin ratios retained, and moderate STH predominance over insulin. In 1/4 of patients with complicated postoperative period and unfavourable outcome an attenuated SAS response was accompanied by excessively high STH, ACTH, cortisol blood content and a lower insulin level, which determined relative insulin insufficiency.

摘要

研究表明,心脏外科手术患者术后早期的病程及其转归在很大程度上与适应性激素的适度平衡有关,这些激素的水平和变化由代偿 - 适应系统的功能状态决定。术后复杂阶段转归良好的患者,交感肾上腺系统(SAS)、垂体肾上腺系统(HAS)同步激活,生长激素(STH)水平升高,同时血液胰岛素含量适度升高,肾上腺素/胰岛素和皮质醇/胰岛素比值保持平衡,且STH相对胰岛素占优势。在术后复杂阶段且转归不良的患者中,四分之一患者的SAS反应减弱,同时伴有STH、促肾上腺皮质激素(ACTH)、血液皮质醇含量过高及胰岛素水平降低,这导致了相对胰岛素不足。

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