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本文引用的文献

1
Quorum-sensing-regulated transcriptional initiation of plasmid transfer and replication genes in Rhizobium leguminosarum biovar viciae.群体感应调控豌豆根瘤菌生物变种中质粒转移与复制基因的转录起始。
Microbiology (Reading). 2007 Jul;153(Pt 7):2074-2082. doi: 10.1099/mic.0.2007/007153-0.
2
Direct evidence for the modulation of the activity of the Erwinia chrysanthemi quorum-sensing regulator ExpR by acylhomoserine lactone pheromone.酰基高丝氨酸内酯信息素对菊欧文氏菌群体感应调节因子ExpR活性进行调控的直接证据。
J Biol Chem. 2006 Oct 6;281(40):29972-87. doi: 10.1074/jbc.M601666200. Epub 2006 Jul 10.
3
The partitioned Rhizobium etli genome: genetic and metabolic redundancy in seven interacting replicons.分区的费氏中华根瘤菌基因组：七个相互作用的复制子中的遗传和代谢冗余
Proc Natl Acad Sci U S A. 2006 Mar 7;103(10):3834-9. doi: 10.1073/pnas.0508502103. Epub 2006 Feb 27.
4
A LuxR/LuxI-type quorum-sensing system in a plant bacterium, Mesorhizobium tianshanense, controls symbiotic nodulation.在植物细菌天山中生根瘤菌中，一种LuxR/LuxI型群体感应系统控制着共生结瘤。
J Bacteriol. 2006 Mar;188(5):1943-9. doi: 10.1128/JB.188.5.1943-1949.2006.
5
Activity of purified QscR, a Pseudomonas aeruginosa orphan quorum-sensing transcription factor.纯化后的铜绿假单胞菌孤儿群体感应转录因子QscR的活性
Mol Microbiol. 2006 Jan;59(2):602-9. doi: 10.1111/j.1365-2958.2005.04960.x.
6
Quorum sensing: cell-to-cell communication in bacteria.群体感应：细菌间的细胞间通讯
Annu Rev Cell Dev Biol. 2005;21:319-46. doi: 10.1146/annurev.cellbio.21.012704.131001.
7
Direct binding of the quorum sensing regulator CepR of Burkholderia cenocepacia to two target promoters in vitro.洋葱伯克霍尔德菌群体感应调节因子CepR在体外与两个靶启动子的直接结合。
Mol Microbiol. 2005 Jul;57(2):452-67. doi: 10.1111/j.1365-2958.2005.04656.x.
8
The cell density-dependent expression of stewartan exopolysaccharide in Pantoea stewartii ssp. stewartii is a function of EsaR-mediated repression of the rcsA gene.斯氏泛菌斯氏亚种中斯图瓦坦胞外多糖的细胞密度依赖性表达是EsaR介导的rcsA基因抑制作用的结果。
Mol Microbiol. 2005 Apr;56(1):189-203. doi: 10.1111/j.1365-2958.2004.04529.x.
9
Amino-terminal protein fusions to the TraR quorum-sensing transcription factor enhance protein stability and autoinducer-independent activity.与群体感应转录因子TraR的氨基末端蛋白质融合可增强蛋白质稳定性和不依赖自诱导物的活性。
J Bacteriol. 2005 Feb;187(4):1219-26. doi: 10.1128/JB.187.4.1219-1226.2005.
10
Promoter specificity in Pseudomonas aeruginosa quorum sensing revealed by DNA binding of purified LasR.纯化的LasR的DNA结合揭示了铜绿假单胞菌群体感应中的启动子特异性。
Proc Natl Acad Sci U S A. 2004 Nov 9;101(45):15833-9. doi: 10.1073/pnas.0407229101. Epub 2004 Oct 25.

LuxR家族群体感应激活剂MrtR的二聚化和激活需要其同源自诱导物，但蛋白质折叠则不需要。

The LuxR family quorum-sensing activator MrtR requires its cognate autoinducer for dimerization and activation but not for protein folding.

作者信息

Yang Menghua, Giel Jennifer L, Cai Tao, Zhong Zengtao, Zhu Jun

机构信息

Department of Microbiology, MOA Key Lab of Microbiological Engineering of Agricultural Environment, Nanjing Agricultural University, Nanjing, China.

出版信息

J Bacteriol. 2009 Jan;191(1):434-8. doi: 10.1128/JB.01247-08. Epub 2008 Oct 31.

DOI:10.1128/JB.01247-08
PMID:18978063
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2612457/
Abstract

MrtR, a LuxR homolog in Mesorhizobium tianshanense, is important for symbiosis. We found that MrtR requires its cognate N-acylhomoserine lactone for forming dimers, binding to a single DNA site and activating the downstream promoter. However, MrtR is able to fold independently of its ligand.

摘要

MrtR是天山中生根瘤菌中一种与LuxR同源的蛋白，对共生至关重要。我们发现，MrtR需要其同源的N-酰基高丝氨酸内酯来形成二聚体、结合单个DNA位点并激活下游启动子。然而，MrtR能够独立于其配体进行折叠。