LuxR家族群体感应激活剂MrtR的二聚化和激活需要其同源自诱导物，但蛋白质折叠则不需要。
The LuxR family quorum-sensing activator MrtR requires its cognate autoinducer for dimerization and activation but not for protein folding.
作者信息
Yang Menghua, Giel Jennifer L, Cai Tao, Zhong Zengtao, Zhu Jun
机构信息
Department of Microbiology, MOA Key Lab of Microbiological Engineering of Agricultural Environment, Nanjing Agricultural University, Nanjing, China.
出版信息
J Bacteriol. 2009 Jan;191(1):434-8. doi: 10.1128/JB.01247-08. Epub 2008 Oct 31.
Abstract
MrtR, a LuxR homolog in Mesorhizobium tianshanense, is important for symbiosis. We found that MrtR requires its cognate N-acylhomoserine lactone for forming dimers, binding to a single DNA site and activating the downstream promoter. However, MrtR is able to fold independently of its ligand.
摘要
MrtR是天山中生根瘤菌中一种与LuxR同源的蛋白，对共生至关重要。我们发现，MrtR需要其同源的N-酰基高丝氨酸内酯来形成二聚体、结合单个DNA位点并激活下游启动子。然而，MrtR能够独立于其配体进行折叠。
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