Styczynski J, Gil L
Department of Pediatric Hematology and Oncology, Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland.
Bone Marrow Transplant. 2008 Oct;42 Suppl 2:S77-81. doi: 10.1038/bmt.2008.289.
Infectious complications constitute a major cause of morbidity and mortality in pediatric and adult patients undergoing hematopoietic SCT (HSCT). Current guidelines and recommendations for prevention of infections in children after HSCT are presented in this mini review. The paper is based on evidence-based recommendations rated by the strength of the recommendation and the quality of the supporting evidence. Prophylaxis strategy based on risk stratification includes: (1) general infection control in hospital environment, (2) pharmacological approach related to antibacterial, antifungal and antiviral agents and (3) vaccination. Although most studies were carried out on adults only, some included both pediatric and adult patients. No differences in prophylaxis strategy and efficacy among age groups are reported. With changing practices, transplant teams are encouraged to review local patterns of prophylaxis strategy.
感染性并发症是接受造血干细胞移植（HSCT）的儿科和成人患者发病和死亡的主要原因。本综述介绍了目前关于HSCT后儿童感染预防的指南和建议。本文基于根据推荐强度和支持证据质量评级的循证推荐。基于风险分层的预防策略包括：（1）医院环境中的一般感染控制，（2）与抗菌、抗真菌和抗病毒药物相关的药理学方法，以及（3）疫苗接种。虽然大多数研究仅在成人中进行，但有些研究纳入了儿科和成人患者。各年龄组在预防策略和疗效方面未报告有差异。随着实践的变化，鼓励移植团队审查当地的预防策略模式。
