Niittynen Leena H, Jauhiainen Tiina A, Poussa Tuija A, Korpela Riitta
Vihti, Finland.
Int J Food Sci Nutr. 2008 Aug;59(5):357-67. doi: 10.1080/09637480701554137.
This study examined the effect of plant sterols added, together with an emulsifying agent, to a low-fat yoghurt on the serum lipid and plant sterol values in moderately hypercholesterolaemic volunteers. Study I was a randomized double-blind, cross-over trial. For 4 weeks, 15 volunteers consumed yoghurt containing 1 g plant sterols or a placebo yoghurt. Study II was a randomized, double-blind, parallel-group study. For 8 weeks, the sterol group (n = 12) ingested daily two yoghurts (2 g/day plant sterols) and the placebo group (n = 14) ingested two yoghurts without plant sterols. Study I: compared with the placebo, the sterol yoghurt reduced serum total cholesterol by 0.15 mmol/l (2.2%, P=0.235) and low-density lipoprotein (LDL) cholesterol by 0.19 mmol/l (4.3%, P=0.082), and increased serum campesterol by 0.26 mg/100 ml (P=0.006) and sitosterol by 0.11 mg/100 ml (P=0.015). Study II: compared with the placebo, the sterol yoghurt reduced serum total cholesterol by 0.41 mmol/l (6.3%, P=0.167) and LDL cholesterol by 0.28 mmol/l (6.4%, P=0.306), and increased serum campesterol by 0.28 mg/100 ml (P=0.016) and sitosterol by 0.40 mg/100 ml (P=0.206). Meta-analysis: the pooled treatment difference was -0.34 mmol/l (5.2%, P=0.173) in total cholesterol and was -0.26 mmol/l (-5.8%, P=0.261) in LDL cholesterol, when the sterol yoghurt was compared with the placebo. A low-fat yoghurt enriched with 1-2 g/day plant sterols reduced serum cholesterol levels in moderately hypercholesterolaemic subjects. Campesterol and sitosterol serum levels increased, but their concentration remained in the range of normal values.
本研究检测了在低脂酸奶中添加植物甾醇及乳化剂，对中度高胆固醇血症志愿者血清脂质和植物甾醇值的影响。研究I为随机双盲交叉试验。15名志愿者连续4周食用含有1克植物甾醇的酸奶或安慰剂酸奶。研究II为随机双盲平行组研究。8周内，甾醇组（n = 12）每天摄入两份酸奶（每天2克植物甾醇），安慰剂组（n = 14）摄入两份不含植物甾醇的酸奶。研究I：与安慰剂相比，甾醇酸奶使血清总胆固醇降低0.15 mmol/l（2.2%，P = 0.235），低密度脂蛋白（LDL）胆固醇降低0.19 mmol/l（4.3%，P = 0.082），血清菜油甾醇增加0.26 mg/100 ml（P = 0.006），谷甾醇增加0.11 mg/100 ml（P = 0.015）。研究II：与安慰剂相比，甾醇酸奶使血清总胆固醇降低0.41 mmol/l（6.3%，P = 0.167），LDL胆固醇降低0.28 mmol/l（6.4%，P = 0.306），血清菜油甾醇增加0.28 mg/100 ml（P = 0.016），谷甾醇增加0.40 mg/100 ml（P = 0.206）。荟萃分析：当将甾醇酸奶与安慰剂相比较时，总胆固醇的合并治疗差异为-0.34 mmol/l（5.2%，P = 0.173），LDL胆固醇的合并治疗差异为-0.26 mmol/l（-5.8%，P = 0.261）。每天富含1 - 2克植物甾醇的低脂酸奶可降低中度高胆固醇血症受试者的血清胆固醇水平。菜油甾醇和谷甾醇的血清水平升高，但其浓度仍保持在正常值范围内。
