Shi Jin, Tian Jie, Xu Min, Yang Wei
Medical Image Processing Group, Institute of Automation Chinese Academy of Science Graduate School of the Chinese Academy of Science.
Med Image Comput Comput Assist Interv. 2008;11(Pt 1):874-82. doi: 10.1007/978-3-540-85988-8_104.
Bioluminescence tomography (BLT) is a promising imaging technique which may dynamically and real-timely detect the molecular and cellular activity at the whole-body level in small animal studies. In view of the ill-posedness of the BLT, it is hard to fully reconstruct source density. In addition, the uniqueness theorem on BLT indicates that it is important to employ a priori information for accurate source reconstruction. Hence, we adopt diffuse optical tomography (DOT) technique to provide optical parameters of main tissues as a priori information. Besides, we restrict the range of real source to a permissible region to raise the numerical stability and reduce the ill-posedness of BLT. Next, we forward Spatial Weighed Element based Finite Element Method and compare it's solutions with analytic formula and MOSE. Numerical simulation of homogeneous and heterogeneous phantom demonstrates the source location and density with prior information is better than that not using a priori information.
生物发光断层扫描（BLT）是一种很有前景的成像技术，在小动物研究中，它可以在全身水平动态实时地检测分子和细胞活动。鉴于BLT的不适定性，很难完全重建源密度。此外，BLT的唯一性定理表明，利用先验信息进行精确的源重建很重要。因此，我们采用扩散光学断层扫描（DOT）技术来提供主要组织的光学参数作为先验信息。此外，我们将真实源的范围限制在一个允许区域，以提高数值稳定性并降低BLT的不适定性。接下来，我们提出基于空间加权单元的有限元方法，并将其解与解析公式和MOSE进行比较。均匀和非均匀体模的数值模拟表明，有先验信息时的源定位和密度比不使用先验信息时更好。
