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脊髓损伤:转化研究的前景

Spinal cord injury: the promise of translational research.

作者信息

Fehlings Michael G, Tighe Allyson

机构信息

Division of Genetics and Development, Toronto Western Research Institute, Toronto, Ontario, Canada.

出版信息

Neurosurg Focus. 2008;25(5):E1. doi: 10.3171/FOC.2008.25.11.E1.

DOI:10.3171/FOC.2008.25.11.E1
PMID:18980469
Abstract

Spinal cord injury (SCI) is a condition with devastating consequences for the patient, family, and society. Although effective treatments for SCI remain limited, there have been many advances in recent years, which have promise for the future from a clinical translational perspective. This issue of Neurosurgical Focus explores some of the current basic science, preclinical, and clinical research directed towards this goal. Clinical investigations are also discussed with regard to the treatment and management of different types of SCI and of SCI in different populations. The issue concludes with a review of the current, ongoing, and planned clinical trials, providing a glimpse of the promising new therapies being developed for the treatment of SCI.

摘要

脊髓损伤(SCI)对患者、家庭和社会都会造成灾难性后果。尽管目前针对脊髓损伤的有效治疗方法仍然有限,但近年来已有许多进展,从临床转化的角度来看,这些进展为未来带来了希望。本期《神经外科聚焦》探讨了一些当前针对这一目标的基础科学、临床前和临床研究。还讨论了不同类型脊髓损伤以及不同人群脊髓损伤的治疗和管理方面的临床研究。本期以对当前正在进行和计划中的临床试验的综述作为结尾,让我们得以一瞥正在研发的用于治疗脊髓损伤的有前景的新疗法。

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Spinal cord injury: the promise of translational research.脊髓损伤:转化研究的前景
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引用本文的文献

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Current Concept of Stem Cell Therapy for Spinal Cord Injury: A Review.脊髓损伤干细胞治疗的当前概念:综述
Korean J Neurotrauma. 2016 Oct;12(2):40-46. doi: 10.13004/kjnt.2016.12.2.40. Epub 2016 Oct 31.
2
Does surgical treatment within 4 hours after trauma have an influence on neurological remission in patients with acute spinal cord injury?创伤后4小时内进行手术治疗对急性脊髓损伤患者的神经功能恢复有影响吗?
Ther Clin Risk Manag. 2016 Aug 31;12:1339-46. doi: 10.2147/TCRM.S108856. eCollection 2016.
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New Prophylactic and Therapeutic Strategies for Spinal Cord Injury.
脊髓损伤的新型预防和治疗策略
J Lifestyle Med. 2013 Mar;3(1):34-40. Epub 2013 Mar 31.
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Current stem cell treatments for spinal cord injury.当前用于脊髓损伤的干细胞治疗方法。
Indian J Orthop. 2012 Jan;46(1):10-8. doi: 10.4103/0019-5413.91629.
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Cellular treatments for spinal cord injury: the time is right for clinical trials.脊髓损伤的细胞治疗:临床试验的时机已经成熟。
Neurotherapeutics. 2011 Oct;8(4):704-20. doi: 10.1007/s13311-011-0076-7.