奥斯特内（Ostene）是一种新型的环氧烷共聚物骨止血材料，不会抑制骨愈合。
Ostene, a new alkylene oxide copolymer bone hemostatic material, does not inhibit bone healing.
作者信息
Magyar Clara E, Aghaloo Tara L, Atti Elisa, Tetradis Sotirios
机构信息
Department of Diagnostic and Surgical Sciences, School of Dentistry, University of California, Los Angeles, California 90095, USA.
出版信息
Neurosurgery. 2008 Oct;63(4 Suppl 2):373-8; discussion 378. doi: 10.1227/01.NEU.0000316859.03788.44.
OBJECTIVE
In this study, we investigate the effects of a soft bone hemostatic wax comprised of water-soluble alkylene oxide copolymers (Ostene; Ceremed, Inc., Los Angeles, CA) on bone healing in a rat calvaria defect model. We compared the effects with a control (no hemostatic agent) and bone wax, an insoluble and nonresorbable material commonly used for bone hemostasis.
METHODS
Two bilateral 3-mm circular noncritical-sized defects were made in the calvariae of 30 rats. Alkylene oxide copolymer or bone wax was applied or no hemostatic material was used (control). After 3, 6, and 12 weeks, rats were sacrificed and the calvariae excised. Bone healing, expressed as fractional bone volume (+/- standard error of the mean), was measured by microcomputed tomography.
RESULTS
Immediate hemostasis was achieved equally with bone wax and alkylene oxide copolymer. Bone wax-filled defects remained unchanged at all time points with negligible healing observed. At 3 weeks, no evidence of alkylene oxide copolymer was observed at the application site, with fractional bone volume significantly greater than bone wax-treated defects (0.20 +/- 0.03 versus 0.02 +/- 0.01; P = 0.0003). At 6 and 12-weeks, alkylene oxide copolymer-treated defects continued to show significantly greater healing versus bone wax (0.18 +/- 0.04 versus 0.05 +/- 0.01 and 0.31 +/- 0.04 versus 0.06 +/- 0.02, respectively). At all time points, alkylene oxide copolymer-treated and control defects showed good healing with no significant difference.
CONCLUSION
Alkylene oxide copolymer is an effective hemostatic agent that does not inhibit osteogenesis or bone healing.
目的
在本研究中，我们调查了一种由水溶性环氧烷共聚物（Ostene；Ceremed公司，加利福尼亚州洛杉矶）组成的软质骨止血蜡对大鼠颅骨缺损模型中骨愈合的影响。我们将其效果与对照组（不使用止血剂）以及骨蜡进行了比较，骨蜡是一种常用于骨止血的不溶性且不可吸收的材料。
方法
在30只大鼠的颅骨上制造两个双侧3毫米圆形非临界尺寸的缺损。应用环氧烷共聚物或骨蜡，或者不使用止血材料（对照组）。在3周、6周和12周后，处死大鼠并切除颅骨。通过微型计算机断层扫描测量骨愈合情况，以骨体积分数（±平均标准误差）表示。
结果
骨蜡和环氧烷共聚物均能同样实现即时止血。填充骨蜡的缺损在所有时间点均保持不变，观察到的愈合可忽略不计。在3周时，在应用部位未观察到环氧烷共聚物的迹象，骨体积分数显著大于骨蜡处理的缺损（0.20±0.03对0.02±0.01；P = 0.0003）。在6周和12周时，环氧烷共聚物处理的缺损与骨蜡相比继续显示出显著更好的愈合效果（分别为0.18±0.04对0.05±0.01和0.31±0.
Zotero 插件