Liu Jinfeng, Li Yongqin, Chen Tianyan, Yang Yuan, Wang Ke, He Yingli, Yang Qian, Ye Feng, Jin Yan, Qiu Ting, Lin Shumei, Liu Min, Zhao Yingren
Department of Infectious Diseases, The First Affiliated Hospital of Xi'an JiaoTong University School of Medicine, 710061, Xi'an, Shaanxi Province, China.
Arch Virol. 2008;153(11):2157-61. doi: 10.1007/s00705-008-0239-y. Epub 2008 Nov 1.
Using a nested-PCR genotyping system, we analyzed the viral genotypes in HBV-infected patients from HBV clustering infection families (CIFs), as compared with HBV infected patients without familial infection history. The patients in the CIF group showed significantly increased prevalence of genotype C infection, while genotype B was absent. Additionally, in the genotype C carriers younger than 50 years old, the prevalence of HCC and LC were significantly increased in CIF compared to the control. We found that HBeAg-positive HBV genotype C carriers are prone to develop end-stage liver diseases earlier than those infected by genotype B.
我们使用巢式聚合酶链反应基因分型系统，分析了来自乙肝病毒聚集感染家庭（CIFs）的乙肝病毒感染患者的病毒基因型，并与无家族感染史的乙肝病毒感染患者进行了比较。CIF组患者中C基因型感染的患病率显著增加，而B基因型不存在。此外，在50岁以下的C基因型携带者中，与对照组相比，CIF组中肝癌和肝硬化的患病率显著增加。我们发现，HBeAg阳性的乙肝病毒C基因型携带者比B基因型感染者更容易更早地发展为终末期肝病。
