Department of Physiology, Anatomy and Genetics, Oxford University, Oxford, UK.
Acta Physiol (Oxf). 2009 Jan;195(1):29-35. doi: 10.1111/j.1748-1716.2008.01919.x. Epub 2008 Oct 28.
Ca(2+) entry through store-operated Ca(2+) release-activated Ca(2+) (CRAC) channels controls a disparate array of key cellular responses. In this review, recent work will be described that shows local Ca(2+) influx through CRAC channels has important spatial and temporal consequences on cell function. A localized Ca(2+) rise below the plasma membrane activates, within tens of seconds, catabolic enzymes resulting in the generation of the intracellular messenger arachidonic acid and the paracrine pro-inflammatory molecule LTC(4). In addition, local Ca(2+) entry can activate gene expression, which develops over tens of minutes. Local Ca(2+) influx through CRAC channels therefore has far-reaching consequences on intra- and intercellular communication.
钙离子通过钙库操纵的钙离子（CRAC）通道内流控制着各种关键的细胞反应。在这篇综述中，将描述最近的研究工作，表明 CRAC 通道的局部钙离子内流对细胞功能具有重要的时空影响。局部的钙离子在质膜下方的上升在数十秒内激活了分解代谢酶，导致细胞内信使花生四烯酸和旁分泌促炎分子 LTC（4）的产生。此外，局部钙离子内流可以激活基因表达，这需要数十分钟的时间。因此，通过 CRAC 通道的局部钙离子内流对细胞内和细胞间的通讯有着深远的影响。
