Brain Imaging & Emotions Laboratory, Department of Psychiatry, University of Chicago, Chicago, IL 60637, USA.
Soc Cogn Affect Neurosci. 2007 Dec;2(4):303-12. doi: 10.1093/scan/nsm029.
Successful control of affect partly depends on the capacity to modulate negative emotional responses through the use of cognitive strategies (i.e., reappraisal). Recent studies suggest the involvement of frontal cortical regions in the modulation of amygdala reactivity and the mediation of effective emotion regulation. However, within-subject inter-regional connectivity between amygdala and prefrontal cortex in the context of affect regulation is unknown. Here, using psychophysiological interaction analyses of functional magnetic resonance imaging data, we show that activity in specific areas of the frontal cortex (dorsolateral, dorsal medial, anterior cingulate, orbital) covaries with amygdala activity and that this functional connectivity is dependent on the reappraisal task. Moreover, strength of amygdala coupling with orbitofrontal cortex and dorsal medial prefrontal cortex predicts the extent of attenuation of negative affect following reappraisal. These findings highlight the importance of functional connectivity within limbic-frontal circuitry during emotion regulation.
成功地控制情绪在一定程度上取决于通过认知策略（即重新评估）来调节负面情绪反应的能力。最近的研究表明，额叶皮质区域参与了杏仁核反应性的调节以及有效的情绪调节的介导。然而，在情绪调节的背景下，杏仁核和前额叶皮层之间的个体内区域连接尚不清楚。在这里，我们使用功能磁共振成像数据的心理生理交互分析表明，前额皮质特定区域（背外侧、背内侧、前扣带、眶额）的活动与杏仁核活动相关，并且这种功能连接依赖于重新评估任务。此外，杏仁核与眶额皮质和背内侧前额皮质的耦合强度预测了重新评估后负面情绪减弱的程度。这些发现强调了情绪调节过程中边缘-前额叶回路内功能连接的重要性。
