Dimopoulou Maria, Kirpensteijn Jolle, Moens Hester, Kik Marja
Department of Small Animal Clinical Sciences, Faculty of Life Sciences, University of Copenhagen, Copenhagen, Denmark.
Vet Surg. 2008 Jul;37(5):466-71. doi: 10.1111/j.1532-950X.2008.00409.x.
To investigate the histologic characteristics of feline osteosarcoma (OS) and compare the histologic data with phenotypically comparable canine OS. The effects of histologic and clinical variables on survival statistics were evaluated.
Retrospective study.
Cats (n=62) and dogs (22).
Medical records of 62 cats with OS were reviewed for clinically relevant data. Clinical outcome was obtained by telephone interview. Histologic characteristics of OS were classified using a standardized grading system. Histologic characteristics in 22 feline skeletal OS were compared with 22 canine skeletal OS of identical location and subtype. Prognostic variables for clinical outcome were determined using multivariate analysis.
Feline OS was characterized by moderate to abundant cellular pleomorphism, low mitotic index, small to moderate amounts of matrix, high cellularity, and a moderate amount of necrosis. There was no significant difference between histologic variables in feline and canine OS. Histologic grade, surgery, and mitotic index significantly influenced clinical outcome as determined by multivariate analysis. Tumor invasion into vessels was not identified as a significant prognosticator.
Feline and canine skeletal OS have similar histologic but different prognostic characteristics.
Prognosis for cats with OS is related to histologic grade and mitotic index of the tumor.
研究猫骨肉瘤（OS）的组织学特征，并将组织学数据与表型相似的犬骨肉瘤进行比较。评估组织学和临床变量对生存统计数据的影响。
回顾性研究。
猫（n = 62）和狗（22只）。
回顾62只患有骨肉瘤的猫的病历以获取临床相关数据。通过电话访谈获得临床结果。使用标准化分级系统对骨肉瘤的组织学特征进行分类。将22例猫骨骼骨肉瘤的组织学特征与22例相同部位和亚型的犬骨骼骨肉瘤进行比较。使用多变量分析确定临床结果的预后变量。
猫骨肉瘤的特征为细胞多形性中度至丰富、有丝分裂指数低、基质含量少至中等、细胞密度高以及坏死量中等。猫和犬骨肉瘤的组织学变量之间无显著差异。多变量分析确定，组织学分级、手术和有丝分裂指数对临床结果有显著影响。肿瘤侵犯血管未被确定为显著的预后指标。
猫和犬骨骼骨肉瘤具有相似的组织学特征，但预后特征不同。
猫骨肉瘤的预后与肿瘤的组织学分级和有丝分裂指数有关。
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