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[为什么要对冠状动脉慢性闭塞病变进行经皮冠状动脉介入治疗以及如何进行?]

[Why perform PCI of coronary chronic occlusion and how?].

作者信息

Louvard Y, Lefèvre T

机构信息

Institut cardiovasculaire Paris Sud, institut hospitalier Jacques-Cartier, 6, rue du Noyer-Lambert, 91300 Massy, France.

出版信息

Ann Cardiol Angeiol (Paris). 2008 Dec;57(6):341-51. doi: 10.1016/j.ancard.2008.10.005. Epub 2008 Oct 16.

Abstract

Angioplasty of coronary chronic total occlusion (CTO), defined by complete occlusion of coronary vessel with TIMI 0 flow greater than 3 months, has been avoided for many years, single vessel diseases being medically treated and multivessel diseases sent to surgeons mainly because a low success and high restenosis rates. Major improvements in devices and techniques mainly coming from Japan created a new concern about when and how to perform PCI of CTO. Clearly CTO are stable lesions but during the last years it was demonstrated that while comparing success and failure of recanalization, success improved symptoms, ischemia, left ventricular function, and even survival. Reopening CTOs can also decrease the risk of death and cardiogenic shock associated with a future acute coronary event. Selection of cases for PCI is based on well-known predictors of failure (calcifications, tortuosities, length of occluded segment and age of occlusion), on operator's experience and on a proof of viability and ischemia of the myocardium depending from occluded vessel (MRI). Many specific devices (powerful wires, microcatheters and coaxial balloons, specific guiding catheters, Tornus) and techniques (anterogrades and retrogrades through trans-septal collateral vessels) have been developed to increase success rate (70 to 90% in high volume operator hands). Outside of coronary perforations which are no more frequent in CTO lesions, some specific problems are important limitations: X-Ray exposure, contrast medium volume, and cost. With the success rate these complications are good reasons to have these procedures (or the most complex) performed by specialists.

摘要

冠状动脉慢性完全闭塞(CTO)的血管成形术,定义为冠状动脉血管完全闭塞且TIMI血流0级持续超过3个月,多年来一直未被采用,单支血管病变采用内科治疗,多支血管病变主要转交给外科医生,主要原因是成功率低和再狭窄率高。主要来自日本的器械和技术的重大改进引发了关于何时以及如何进行CTO经皮冠状动脉介入治疗(PCI)的新关注。显然,CTO是稳定病变,但在过去几年中已证明,在比较再通的成功与失败时,成功可改善症状、缺血、左心室功能,甚至生存率。开通CTO还可降低与未来急性冠状动脉事件相关的死亡和心源性休克风险。PCI病例的选择基于众所周知的失败预测因素(钙化、迂曲、闭塞段长度和闭塞时间)、术者经验以及取决于闭塞血管的心肌存活和缺血证据(MRI)。已经开发了许多特定的器械(强力导丝、微导管和同轴球囊、特定的指引导管、Tornus)和技术(通过经间隔侧支血管的正向和逆向技术)以提高成功率(在经验丰富的术者手中为70%至90%)。除了CTO病变中不再常见的冠状动脉穿孔外,一些特定问题是重要的限制因素:X线暴露、造影剂用量和费用。鉴于成功率,这些并发症是由专家进行这些手术(或最复杂的手术)的充分理由。

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