Umsawasdi T, Dhingra H M, Charnsangavej C, Luna M A
Department of Medical Oncology, University of Texas M.D. Anderson Cancer Center, Houston 77030.
Cancer. 1991 Jan 1;67(1):48-54. doi: 10.1002/1097-0142(19910101)67:1<48::aid-cncr2820670110>3.0.co;2-i.
Long duration of responses to chemotherapy in patients with malignant pleural mesothelioma (MPM) is rare. The authors report a patient with inoperable MPM who achieved complete remission with combination chemotherapy of cyclophosphamide, doxorubicin, and cisplatin. 5-fluorouracil and mitomycin C (FM) induced another remission after recurrence of the tumor. Retreatment with FM after chemotherapy had been stopped for 20 months yielded another continuing response. The overall tumor-control time is more than 4 years. Literature reviews and the authors' results suggest that MPM may be a chemosensitive tumor in some patients. Additional evaluations of CAP, FM, and methotrexate combination regimens in this disease should be considered.
恶性胸膜间皮瘤（MPM）患者对化疗的长期反应很少见。作者报告了1例无法手术的MPM患者，其通过环磷酰胺、阿霉素和顺铂联合化疗实现了完全缓解。肿瘤复发后，5-氟尿嘧啶和丝裂霉素C（FM）诱导了另一次缓解。化疗停止20个月后用FM再次治疗产生了另一次持续反应。总的肿瘤控制时间超过4年。文献综述和作者的结果表明，MPM在某些患者中可能是一种对化疗敏感的肿瘤。应考虑对该疾病中CAP、FM和甲氨蝶呤联合方案进行进一步评估。
