Guy Mark, Newall Ronald, Borzomato Joanna, Kalra Philip A, Price Christopher
Department of Clinical Biochemistry, Salford Royal NHS Foundation Trust, Salford, UK.
Nephrol Dial Transplant. 2009 Apr;24(4):1189-93. doi: 10.1093/ndt/gfn612. Epub 2008 Nov 5.
Urine protein strip tests are often used in the ward or clinic as first-line measures of proteinuria. The ability of a semi-quantitative meter-read strip test for the protein:creatinine ratio, Multistix* PRO 10LS (Siemens Medical Solutions, Tarrytown, USA), was assessed as a first-line test to exclude significant proteinuria in the monitoring of patients with established chronic kidney disease.
Eighty-six patients attending a hospital renal outpatient clinic collected three random urine samples during a 24-h period. Random urine protein:creatinine ratios measured by the strip test were compared to the laboratory estimation of 24-h protein excretion on that same day.
At significant protein excretion of 0.3 g/24 h, the strips elicited negative predictive values in the range of 91.2-94.1% and negative likelihood ratios of 0.01-0.12, using all the random urines. Receiver-operator characteristic curve analysis also demonstrated good performance with all samples.
The strip test allows the physician to rule out significant proteinuria at the patient consultation on a random urine sample, obviating the need for specially collected samples, and with the added benefit of reducing the need for a lengthy and costly quantitative laboratory follow-up by approximately 40-48%.
尿蛋白试纸条检测常用于病房或门诊，作为蛋白尿的一线检测方法。对一种用于检测蛋白：肌酐比值的半定量血糖仪读数试纸条检测方法（Multistix* PRO 10LS，西门子医疗解决方案公司，美国塔里敦）进行评估，将其作为监测已确诊慢性肾脏病患者时排除显著蛋白尿的一线检测方法。
86名在医院肾脏门诊就诊的患者在24小时内收集了3份随机尿液样本。将试纸条检测测得的随机尿蛋白：肌酐比值与同一天实验室对24小时尿蛋白排泄量的估计值进行比较。
在24小时尿蛋白排泄量达到0.3 g时，使用所有随机尿液样本，试纸条检测的阴性预测值范围为91.2%至94.1%，阴性似然比为0.01至0.12。受试者工作特征曲线分析也表明所有样本的检测性能良好。
试纸条检测可使医生在患者就诊时通过随机尿液样本排除显著蛋白尿，无需专门采集样本，还有额外的好处，即可将冗长且昂贵的定量实验室后续检测需求减少约40%至48%。
