Bertout Jessica A, Patel Shetal A, Simon M Celeste
Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Nat Rev Cancer. 2008 Dec;8(12):967-75. doi: 10.1038/nrc2540. Epub 2008 Nov 6.
During the past century it has been established that regions within solid tumours experience mild to severe O(2) deprivation owing to aberrant vascular function. These hypoxic regions are associated with altered cellular metabolism, as well as increased resistance to radiation and chemotherapy. As discussed in this Timeline, over the past decade work from many laboratories has elucidated the mechanisms by which hypoxia-inducible factors (HIFs) modulate tumour cell metabolism, angiogenesis, growth and metastasis. The central role played by intra-tumoural hypoxia and HIF in these processes has made them attractive therapeutic targets in the treatment of multiple human malignancies.
在过去的一个世纪里，已经证实实体瘤内的区域由于血管功能异常而经历轻度至重度的氧气剥夺。这些缺氧区域与细胞代谢改变以及对放疗和化疗的抗性增加有关。正如本时间轴中所讨论的，在过去十年中，许多实验室的研究阐明了缺氧诱导因子（HIFs）调节肿瘤细胞代谢、血管生成、生长和转移的机制。肿瘤内缺氧和HIF在这些过程中所起的核心作用使其成为治疗多种人类恶性肿瘤的有吸引力的治疗靶点。
