幽门螺杆菌胃炎与缺血性中风风险

Helicobacter pylori gastritis and risk of ischaemic stroke.

作者信息

Wasay Mohammad, Jafri Wasim, Khealani Bhojo, Azam Iqbal, Hussaini Akber

机构信息

Department of Medicine, The Aga Khan University, Karachi.

出版信息

J Pak Med Assoc. 2008 Jul;58(7):368-70.

PMID:18988408

Abstract

OBJECTIVE

To identify the association between H. Pylori gastritis and stroke.

METHOD

Patients with biopsy proven H. Pylori gastritis and non H. Pylori gastritis were enrolled. Patients were followed for a period of two years.

RESULTS

A total of 326 patients were included in the study. 162 patients were with H. Pylori gastritis. There was no significance difference in age, sex and duration of symptoms in the two groups. Three patients in H. Pylori group had stroke or TIA as compared to one in non H. Pylori group. Patients with H. Pylori gastritis were more likely to die or have cardiac and or neurological event as compared to Non H. pylori gastritis (OR 1.23, 95% CI 0.89-1.67). This relationship was not significant after adjusting for cardiovascular risk factors (AOR 0.85, 95% CI 0.45-1.31).

CONCLUSION

H. Pylori gastritis is not independently associated with increased risk for stroke. Larger, randomized studies are needed to confirm our findings.

摘要

目的

确定幽门螺杆菌胃炎与中风之间的关联。

方法

纳入经活检证实为幽门螺杆菌胃炎和非幽门螺杆菌胃炎的患者。对患者进行为期两年的随访。

结果

本研究共纳入326例患者。162例患者患有幽门螺杆菌胃炎。两组在年龄、性别和症状持续时间方面无显著差异。幽门螺杆菌组有3例发生中风或短暂性脑缺血发作，而非幽门螺杆菌组有1例。与非幽门螺杆菌胃炎患者相比，幽门螺杆菌胃炎患者更有可能死亡或发生心脏和/或神经事件（比值比1.23，95%置信区间0.89 - 1.67）。在调整心血管危险因素后，这种关系不显著（校正比值比0.85，95%置信区间0.45 - 1.31）。