阿德福韦联合丙型肝炎病毒治疗可能预防乙肝和丙肝病毒携带者在丙肝病毒根除后出现乙肝再激活。

Adefovir combined with hepatitis C virus treatment may prevent hepatitis B reactivation after hepatitis C virus eradication in hepatitis B and C virus carriers.

作者信息

Renou Christophe, Cadranel Jean-François, Pariente Alexandre, Pénaranda Guillaume, Bourlière Marc, Halfon Philippe, Igual Jean-Pierre, Harafa Abdelouahid, Muller Pierre, Bertrand Jean-Jacques, Laugier René

机构信息

Gastroenterology Department, Hyères Hospital, Hyères, France.

出版信息

Eur J Gastroenterol Hepatol. 2008 Dec;20(12):1235-7. doi: 10.1097/MEG.0b013e328305ba2a.

DOI:10.1097/MEG.0b013e328305ba2a

PMID:18989147

Abstract

This observation reports that a hepatitis B virus (HBV) reactivation, as the result of hepatitis C virus (HCV) eradication on a dominant HCV coinfected HBV/HCV patient, was subsequently prevented by treating both viral infections together. This finding raises the question as to whether preemptive HBV treatment should be prescribed along with HCV treatment to prevent HBV from being reactive after HCV eradication in coinfected HBV/HCV patients.

摘要

本观察报告称，在一名以丙型肝炎病毒（HCV）为主的HBV/HCV合并感染患者中，丙型肝炎病毒清除导致了乙型肝炎病毒（HBV）再激活，随后通过同时治疗两种病毒感染预防了这种情况。这一发现提出了一个问题，即在合并感染HBV/HCV的患者中，在进行丙型肝炎病毒治疗时是否应同时进行预防性HBV治疗，以防止丙型肝炎病毒清除后HBV再激活。