血清素受体2A阻滞剂（利培酮）对人多瘤病毒JC感染原代人胎儿神经胶质细胞没有影响。
Serotonin receptor 2A blocker (risperidone) has no effect on human polyomavirus JC infection of primary human fetal glial cells.
作者信息
Chapagain Moti L, Sumibcay Laarni, Gurjav Ulziijargal, Kaufusi Pakieli H, Kast Richard E, Nerurkar Vivek R
机构信息
Retrovirology Research Laboratory, Department of Tropical Medicine, Medical Microbiology and Pharmacology, Asia-Pacific Institute of Tropical Medicine and Infectious Diseases, John A. Burns School of Medicine, Honolulu, Hawaii 96813, USA.
出版信息
J Neurovirol. 2008 Oct;14(5):448-54. doi: 10.1080/13550280802235916. Epub 2008 Nov 12.
Abstract
A recent report demonstrated that JC virus (JCV) employs serotonin receptor 2A (5HT(2A)R) to infect the glial cells. To assess the ability of a potent 5HT(2A)R blocker, risperidone, to inhibit JCV infection, the authors treated primary human fetal glial (PHFG) cells in vitro with risperidone for 24 h and inoculated with JCV(Mad1). There was no significant difference in JCV genome copies or mRNA transcripts and protein expression in treatment-naive and risperidone-treated PHFG cells. These data indicate that risperidone does not inhibit JCV(Mad1) attachment, internalisation, and replication in PHFG cells, and 5HT(2A)R blockers may not be effective in treating progressive multifocal leukoencephalopathy (PML).
摘要
最近的一份报告表明，JC病毒（JCV）利用5-羟色胺受体2A（5HT(2A)R）感染神经胶质细胞。为了评估强效5HT(2A)R阻滞剂利培酮抑制JCV感染的能力，作者在体外用利培酮处理原代人胎儿神经胶质（PHFG）细胞24小时，然后接种JCV（Mad1）。未处理的和经利培酮处理的PHFG细胞中的JCV基因组拷贝数、mRNA转录本及蛋白表达没有显著差异。这些数据表明，利培酮不抑制JCV（Mad1）在PHFG细胞中的附着、内化及复制，并且5HT(2A)R阻滞剂可能对进行性多灶性白质脑病（PML）治疗无效。
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