Department of Chemistry, The Scripps Research Institute MB-26, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.
Org Lett. 2008 Dec 4;10(23):5397-400. doi: 10.1021/ol8022775.
A deep, self-folding cavitand responds to minor electronic differences between suitably sized adamantane guests. Binding constants range from <0.5 to 4000 M(-1) for guests as similar as 1-bromoadamantane and 1-cyanoadamantane. The barriers to guest exchange also vary up to 3 kcal mol(-1).
一种深度的、自折叠的穴状配体可以响应大小合适的金刚烷客体之间的微小电子差异。对于像 1-溴代金刚烷和 1-氰基金刚烷这样相似的客体,结合常数的范围从<0.5 到 4000 M(-1)。客体交换的障碍也高达 3 kcal mol(-1)。