Gilbert Donald L
Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229, USA.
Ann N Y Acad Sci. 2008 Oct;1142:72-84. doi: 10.1196/annals.1444.005.
This article reviews the current state of knowledge of drug-induced movement disorders (DIMDs) in children. The objective is to aid clinicians who treat children with medications that may induce DIMDs, as well as specialists consulted on DIMDs. As with adults, the most common agents are dopaminergic and dopamine-blocking medications, and prescriptions for these agents have increased markedly in children. Unfortunately, most evidence-based reviews, including those from the Cochrane Collaboration cited here, have few systematic data to analyze. Many publications are small case series. This report attempts to provide useful information, with appropriate caution and discussion of the limitations of what we know.
本文综述了儿童药物性运动障碍(DIMDs)的当前知识状况。目的是帮助治疗可能诱发DIMDs药物的儿童的临床医生,以及就DIMDs进行咨询的专家。与成人一样,最常见的药物是多巴胺能和多巴胺阻断药物,这些药物在儿童中的处方量显著增加。不幸的是,包括本文引用的Cochrane协作网的那些在内,大多数基于证据的综述几乎没有可供分析的系统数据。许多出版物都是小型病例系列。本报告试图提供有用的信息,同时适当谨慎并讨论我们所了解内容的局限性。