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儿童群体中的震颤:临床特征、鉴别诊断及管理挑战

Tremor in Pediatric Populations: Clinical Characteristics, Differential Diagnosis, and Management Challenges.

作者信息

Ghadery Christine M, Gorodetsky Carolina, Lang Anthony E

机构信息

Department of Medicine, Edmond J. Safra Program in Parkinson's Disease, University Health Network and the Division of Neurology; University of Toronto, Toronto, Ontario, Canada.

Department of Pediatrics, Division of Neurology, The Hospital for Sick Children; University of Toronto, Toronto, Ontario, Canada.

出版信息

Mov Disord Clin Pract. 2025 Jun;12(6):734-750. doi: 10.1002/mdc3.70008. Epub 2025 Mar 24.

Abstract

BACKGROUND

Tremor is a hyperkinetic movement disorder defined as a rhythmic, involuntary, oscillatory movement of a body part. It can present as early as in the neonatal period and may be an isolated finding or part of an associated neurological or systemic disorder. Although it is commonly seen in childhood, it is not frequently described in the literature.

OBJECTIVES

This review aims to provide a clinically useful overview of pediatric tremors based on the current literature.

METHODS

We identified relevant studies published in English by searching PubMed (until February 2024), using the following subject headings: pediatric/tremor, deep brain stimulation, and focused ultrasound.

RESULTS

Data from 65 articles were critically reviewed with focus on tremor classification, etiologies, clinical features, and management.

CONCLUSION

Some tremor disorders in children can persist into adulthood, however, others are exclusively seen in the pediatric population. The lack of epidemiological and clinical studies in the pediatric population creates substantial challenges for pediatricians, and medical decisions are mostly guided by adult data.

摘要

背景

震颤是一种运动亢进性疾病,定义为身体某一部位有节奏的、不自主的摆动。它最早可在新生儿期出现,可能是孤立的表现,也可能是相关神经或全身性疾病的一部分。尽管震颤在儿童期很常见,但在文献中却不常被描述。

目的

本综述旨在根据当前文献,提供一份对儿童震颤具有临床实用价值的概述。

方法

我们通过检索PubMed(截至2024年2月),使用以下主题词:儿科/震颤、深部脑刺激和聚焦超声,来识别以英文发表的相关研究。

结果

对65篇文章的数据进行了严格审查,重点关注震颤的分类、病因、临床特征和治疗。

结论

儿童的一些震颤疾病可持续到成年期,然而,其他一些震颤疾病仅见于儿科人群。儿科人群中缺乏流行病学和临床研究给儿科医生带来了巨大挑战,医疗决策大多以成人数据为指导。

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