亚甲基四氢叶酸还原酶和胸苷酸合成酶增强子区域多态性对韩国人群特发性复发性自然流产风险的影响。
Effect of methylenetetrahydrofolate reductase and thymidylate synthase enhancer region polymorphisms on the risk of idiopathic recurrent spontaneous abortion in a Korean population.
作者信息
Bae Jeehyeon, Choi Dong Hee, Kang Myung Seo, Cha Sun Hee, Oh Doyeun, Kim Nam Keun
机构信息
Institute for Clinical Research, Bundang CHA General Hospital, College of Medicine, Pochon CHA University, Seongnam, South Korea.
出版信息
Fertil Steril. 2009 Apr;91(4 Suppl):1560-2. doi: 10.1016/j.fertnstert.2008.09.060. Epub 2008 Nov 6.
Previous studies reported an association of methylenetetrahydrofolate reductase (MTHFR) polymorphisms and recurrent spontaneous abortion, whereas no studies are available for the association with thymidylate synthase enhancer region (TSER) genotypes. Mutations of MTHFR and TSER are not likely significant risk factors of idiopathic recurrent spontaneous abortion in Korean women.
先前的研究报道了亚甲基四氢叶酸还原酶（MTHFR）基因多态性与复发性自然流产之间的关联，而关于其与胸苷酸合成酶增强子区域（TSER）基因型之间关联的研究尚无报道。MTHFR和TSER的突变不太可能是韩国女性特发性复发性自然流产的显著风险因素。
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