Gosak Marko
Department of Physics, Faculty of Natural Sciences and Mathematics, University of Maribor, Koroska cesta 160, SI-2000 Maribor, Slovenia.
Biophys Chem. 2009 Jan;139(1):53-6. doi: 10.1016/j.bpc.2008.10.001. Epub 2008 Oct 25.
Calcium ions are an important second messenger in living cells. Calcium signals in form of waves serve as a means of intercellular communication and thus represent a vibrant subject for experimental and theoretical investigations. Here we study the role of cellular variability on the occurrence of Ca2+ wave propagation in a net of diffusively coupled cells. Dynamics of individual cells is simulated by a mathematical model for Ca2+ oscillations. Structural diversity of cells is introduced via variations of the bifurcation parameters, which signify cell sensitivity for external stimulation. Remarkably, for sufficient values of variability Ca2+ waves emerge, which are mostly ordered for intermediate variability strength. We analyze the spatial profile via the autocorrelation function, which confirms a resonance-like response due to the cellular variability. Thus, the reported phenomenon is a novel observation of diversity-induced spatial coherence resonance in a tissue-like media.
钙离子是活细胞中重要的第二信使。以波的形式存在的钙信号作为细胞间通讯的一种方式，因此是实验和理论研究的一个活跃主题。在这里，我们研究细胞变异性在扩散耦合细胞网络中Ca2+波传播发生过程中的作用。通过Ca2+振荡的数学模型模拟单个细胞的动力学。通过分岔参数的变化引入细胞的结构多样性，分岔参数表示细胞对外部刺激的敏感性。值得注意的是，对于足够大的变异性值，会出现Ca2+波，在中等变异性强度下，这些波大多是有序的。我们通过自相关函数分析空间分布，这证实了由于细胞变异性而产生的类似共振的响应。因此，所报道的现象是在组织样介质中多样性诱导的空间相干共振的一种新观察。
