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氧杂菌素，一种涉及8-羟基喹啉亚基的与肠杆菌素类似的铁载体：合成及铁结合能力

Oxinobactin, a siderophore analogue to enterobactin involving 8-hydroxyquinoline subunits: synthesis and iron binding ability.

作者信息

d'Hardemare Amaury du Moulinet, Alnaga Nivine, Serratrice Guy, Pierre Jean-Louis

机构信息

Département de Chimie Moléculaire (UMR 5250), Université Joseph Fourier-Grenoble, 301 rue de la Chimie, BP 53X, 38041 Grenoble cedex 9, France.

出版信息

Bioorg Med Chem Lett. 2008 Dec 15;18(24):6476-8. doi: 10.1016/j.bmcl.2008.10.060. Epub 2008 Oct 17.

DOI:10.1016/j.bmcl.2008.10.060
PMID:18990573
Abstract

Oxinobactin, a siderophore analogue to enterobactin but possessing 8-hydroxyquinoline instead of catechol complexing subunits, has been synthesized starting from L-serine and 8-hydroxyquinoline. Comparative iron binding studies showed that oxinobactin is as effective as enterobactin for the complexation of Fe(III) at physiological pH but with improved complexing ability at acidic pH.

摘要

氧肟酸菌素是一种与肠杆菌素类似的铁载体，但具有8-羟基喹啉而非儿茶酚络合亚基，它是从L-丝氨酸和8-羟基喹啉开始合成的。对比铁结合研究表明，在生理pH值下，氧肟酸菌素与肠杆菌素在络合Fe(III)方面效果相当，但在酸性pH值下具有更好的络合能力。

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