Wible C G, Lee K, Molina I, Hashimoto R, Preus A P, Roach B J, Ford J M, Mathalon D H, McCarthey G, Turner J A, Potkin S G, O'Leary D, Belger A, Diaz M, Voyvodic J, Brown G G, Notestine R, Greve D, Lauriello J
Department of Psychiatry, Harvard Medical School and Brockton VAMC, Boston, MA 02115, USA.
Schizophr Bull. 2009 Jan;35(1):47-57. doi: 10.1093/schbul/sbn142. Epub 2008 Nov 5.
Auditory hallucinations are a hallmark symptom of schizophrenia. The neural basis of auditory hallucinations was examined using data from a working memory task. Data were acquired within a multisite consortium and this unique dataset provided the opportunity to analyze data from a large number of subjects who had been tested on the same procedures across sites. We hypothesized that regions involved in verbal working memory and language processing would show activity that was associated with levels of hallucinations during a condition where subjects were rehearsing the stimuli.
Data from the Sternberg Item Recognition Paradigm, a working memory task, were acquired during functional magnetic resonance imaging procedures. The data were collected and preprocessed by the functional imaging biomedical informatics research network consortium. Schizophrenic subjects were split into nonhallucinating and hallucinating subgroups and activity during the probe condition (in which subjects rehearsed stimuli) was examined. Levels of activation from contrast images for the probe phase (collapsed over levels of memory load) of the working memory task were also correlated with levels of auditory hallucinations from the Scale for the Assessment of Positive Symptoms scores.
Patients with auditory hallucinations (relative to nonhallucinating subjects) showed decreased activity during the probe condition in verbal working memory/language processing regions, including the superior temporal and inferior parietal regions. These regions also showed associations between activity and levels of hallucinations in a correlation analysis.
The association between activation and hallucinations scores in the left hemisphere language/working memory regions replicates the findings of previous studies and provides converging evidence for the association between superior temporal abnormalities and auditory hallucinations.
幻听是精神分裂症的标志性症状。我们使用一项工作记忆任务的数据来研究幻听的神经基础。数据是在一个多中心联盟内采集的，这个独特的数据集提供了一个机会，可以分析大量在不同地点接受相同程序测试的受试者的数据。我们假设，在受试者对刺激进行复述的情况下，参与言语工作记忆和语言处理的区域会表现出与幻觉水平相关的活动。
在功能磁共振成像过程中获取了来自斯特恩伯格项目识别范式（一项工作记忆任务）的数据。这些数据由功能成像生物医学信息学研究网络联盟收集和预处理。将精神分裂症患者分为无幻觉亚组和有幻觉亚组，并检查在探测条件（受试者复述刺激时）下的活动。工作记忆任务探测阶段（跨越记忆负荷水平汇总）的对比图像的激活水平也与阳性症状评估量表中幻听水平相关。
有幻听的患者（相对于无幻觉的受试者）在探测条件下，在言语工作记忆/语言处理区域，包括颞上叶和顶下叶区域，表现出活动减少。在相关性分析中，这些区域的活动与幻觉水平之间也存在关联。
左半球语言/工作记忆区域的激活与幻觉评分之间的关联重复了先前研究的结果，并为颞上叶异常与幻听之间的关联提供了趋同证据。
