Turner C E, Kramarcy N, Sealock R, Burridge K
Department of Cell Biology and Anatomy, University of North Carolina, Chapel Hill 27599-7090.
Exp Cell Res. 1991 Feb;192(2):651-5. doi: 10.1016/0014-4827(91)90090-h.
In this report we have demonstrated that paxillin, a cytoskeletal protein which is present in focal adhesions, localizes in vivo to regions of cell-extracellular matrix interaction which are believed to be analogous to focal adhesions. Specifically, it is enriched in the dense plaques of chicken gizzard smooth muscle tissue and in the myotendinous junctions formed in Xenopus laevis tadpole tail skeletal muscle. In addition, paxillin was identified at the rat diaphragm neuromuscular junction. The distribution of paxillin is thus comparable to that of other focal adhesion proteins, for example, talin and vinculin, in these structures.
在本报告中，我们已证明桩蛋白是一种存在于粘着斑中的细胞骨架蛋白，在体内定位于细胞与细胞外基质相互作用的区域，这些区域被认为类似于粘着斑。具体而言，它在鸡胗平滑肌组织的致密斑以及非洲爪蟾蝌蚪尾部骨骼肌中形成的肌腱连接中富集。此外，在大鼠膈肌神经肌肉接头处也鉴定出了桩蛋白。因此，在这些结构中，桩蛋白的分布与其他粘着斑蛋白（例如踝蛋白和纽蛋白）的分布相当。
