Gobin Andre M, Moon James J, West Jennifer L
Department of Bioengineering, Rice University, Houston, TX 77251-1892, USA.
Int J Nanomedicine. 2008;3(3):351-8.
Gold-coated silica nanoshells are a class of nanoparticles that can be designed to possess strong absorption of light in the near infrared (NIR) wavelength region. When injected intravenously, these nanoshells have been shown to accumulate in tumors and subsequently mediate photothermal treatment, leading to tumor regression. In this work, we sought to improve their specificity by targeting them to prostate tumor cells. We report selective targeting of PC-3 cells with nanoshells conjugated to ephrinA I, a ligand for EphA2 receptor that is overexpressed on PC-3 cells. We demonstrate selective photo-thermal destruction of these cells upon application of the NIR laser.
金包覆二氧化硅纳米壳是一类纳米颗粒，可设计为在近红外（NIR）波长区域具有强烈的光吸收能力。静脉注射后，这些纳米壳已被证明会在肿瘤中积聚，并随后介导光热治疗，从而导致肿瘤消退。在这项工作中，我们试图通过将它们靶向前列腺肿瘤细胞来提高其特异性。我们报告了用与ephrinA I偶联的纳米壳对PC-3细胞进行选择性靶向，ephrinA I是EphA2受体的配体，在PC-3细胞上过度表达。我们证明了在应用近红外激光后，这些细胞会被选择性光热破坏。
