Ginther O J, Jacob J C, Gastal M O, Gastal E L, Beg M A
Eutheria Foundation, Cross Plains, WI 53528, USA.
Reprod Domest Anim. 2009 Jun;44(3):441-9. doi: 10.1111/j.1439-0531.2008.01109.x. Epub 2008 Oct 23.
Ablation of follicles > or = 6 mm in diameter and treatment with PGF2alpha 10 days after ovulation were used to induce the development of ovulatory waves. Comparisons were made between induced waves with one (33 waves, 72%) and multiple (13 waves, 28%) ovulatory follicles. Diameter deviation was defined as the separation of follicles into dominant and subordinate categories. Multiple ovulatory follicles were preceded by more (p < 0.001) follicles > or = 20 mm at the beginning of deviation, higher LH preceding deviation (approached significance, p < 0.08), lower (p < 0.05) concentrations of FSH on the day of deviation and thereafter, and higher (p < 0.0003) oestradiol by 2 days after deviation. During the peri-ovulatory period, systemic hormone concentrations for waves with multiple ovulations involved higher oestradiol before ovulation (approached significance, p < 0.07), lower FSH (p < 0.04) before and after ovulation, and both higher progesterone (p < 0.05) and lower LH (p < 0.05) beginning the day after ovulation. Results indicated that by the beginning of deviation there were more follicles > or = 20 mm and subsequently greater oestradiol production in waves that led to the development of multiple ovulatory follicles, and during the peri-ovulatory period differences between one and multiple ovulations were consistent with the negative effects of the ovarian hormones on the gonadotropins.
对直径大于或等于6毫米的卵泡进行消融，并在排卵后10天用PGF2α进行处理，以诱导排卵波的发育。对有一个（33个波，72%）和多个（13个波，28%）排卵卵泡的诱导波进行了比较。直径偏差定义为卵泡分为优势卵泡和从属卵泡。在偏差开始时，多个排卵卵泡之前有更多（p<0.001）直径大于或等于20毫米的卵泡，偏差前LH水平较高（接近显著水平，p<0.08），偏差当天及之后FSH浓度较低（p<0.05），偏差后2天雌二醇水平较高（p<0.0003）。在围排卵期，多次排卵波的全身激素浓度在排卵前雌二醇水平较高（接近显著水平，p<0.07），排卵前后FSH水平较低（p<0.04），排卵后第一天孕酮水平较高（p<0.05）且LH水平较低（p<0.05）。结果表明，在偏差开始时，导致多个排卵卵泡发育的波中有更多直径大于或等于20毫米的卵泡，随后雌二醇产量更高，并且在围排卵期，单次排卵和多次排卵之间的差异与卵巢激素对促性腺激素的负面影响一致。
