肺黏液表皮样癌、对表皮生长因子受体（EGFR）抑制剂的反应、EGFR和K-RAS突变以及鉴别诊断
Mucoepidermoid carcinoma of the lung, response to EGFR inhibitors, EGFR and K-RAS mutations, and differential diagnosis.
作者信息
Rossi Giulio, Sartori Giuliana, Cavazza Alberto, Tamberi Stefano
出版信息
Lung Cancer. 2009 Jan;63(1):159-60. doi: 10.1016/j.lungcan.2008.09.007. Epub 2008 Nov 6.
Abstract
Mucoepidermoid carcinoma (MEC) of the lung needs to be carefully distinguished from other lung tumors with similar features, particularly from adenosquamous carcinoma, this latter tumor frequently showing EGFR mutations. In contrast with the data reported by Han et al in the last July issue of Lung Cancer, neither EGFR nor K-RAS mutations were observed in MEC from caucasian patients.
摘要
肺黏液表皮样癌（MEC）需要与具有相似特征的其他肺部肿瘤仔细鉴别，尤其是与腺鳞癌相鉴别，后者常显示表皮生长因子受体（EGFR）突变。与韩等人在去年7月《肺癌》杂志上报道的数据相反，在白种人患者的MEC中未观察到EGFR和K-RAS突变。
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