从牛脑中分离并鉴定α-（β-丙氨酰）-赖胺酰腐胺
Isolation and identification of alpha-(beta-alanyl)hypusine from bovine brain.
作者信息
Ueno S, Kotani K, Sano A, Kakimoto Y
机构信息
Department of Neuropsychiatry, Ehime University, School of Medicine, Japan.
出版信息
Biochim Biophys Acta. 1991 Jan 23;1073(1):233-5. doi: 10.1016/0304-4165(91)90209-y.
PMID:1899342
Abstract
A unique dipeptide was isolated from bovine brain using five steps of ion-exchange chromatography. Its acid hydrolysate contained equimolar amounts of beta-alanine and hypusine. The structure of the peptide was elucidated as alpha-(beta-alanyl)hypusine using dansylation technique. About 1 mumol of the compound was isolated from 1090 g of bovine brain.
摘要
采用五步离子交换色谱法从牛脑中分离出一种独特的二肽。其酸水解产物含有等摩尔量的β-丙氨酸和hypusine。使用丹磺酰化技术确定该肽的结构为α-(β-丙氨酰)hypusine。从1090克牛脑中分离出约1微摩尔的该化合物。
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