Martinez A R, Bernardus R E, Voorhorst F J, Vermeiden J P, Schoemaker J
Department of Obstetrics and Gynecology, Free University Hospital, Amsterdam, The Netherlands.
Fertil Steril. 1991 Feb;55(2):258-65. doi: 10.1016/s0015-0282(16)54112-0.
Forty-eight patients with male (n = 16) or idiopathic (n = 32) infertility were stimulated with human menopausal gonadotropin. Intrauterine insemination (IUI) or natural intercourse were performed after either human chorionic gonadotropin (hCG)-induced or spontaneous, urinary luteinizing hormone (LH) surge-monitored ovulation. A total of 148 cycles were analyzed. In 40 cycles treated with hCG-induced ovulation and IUI, 3 (7.5%) patients conceived, whereas 37 women accomplished natural intercourse after hCG-induced ovulation and 2 (5.5%) became pregnant. When inseminated after a spontaneous LH surge, 3 (8.8%) of 34 patients achieved a pregnancy; no conception occurred in 37 spontaneously ovulatory cycles combined with timed intercourse. Pregnancy rates did not substantially differ between the treatment modalities or between mono-ovulatory and polyovulatory cycles. The cycle characteristics between spontaneous ovulatory and hCG-induced cycles significantly did differ.
48例男性因素（n = 16）或特发性（n = 32）不育患者接受了人绝经期促性腺激素刺激。在人绒毛膜促性腺激素（hCG）诱导排卵或自然发生的、通过尿促黄体生成素（LH）峰监测的排卵后，进行了宫腔内人工授精（IUI）或自然性交。共分析了148个周期。在40个经hCG诱导排卵并进行IUI治疗的周期中，3例（7.5%）患者受孕，而37名女性在hCG诱导排卵后进行自然性交，2例（5.5%）怀孕。在自发LH峰后进行人工授精时，34例患者中有3例（8.8%）怀孕；37个自发排卵周期与定时性交相结合未发生受孕。治疗方式之间或单排卵周期与多排卵周期之间的妊娠率无显著差异。自发排卵周期和hCG诱导周期之间的周期特征确实存在显著差异。
