Imoedemhe D A, Sigue A B, Pacpaco E L, Olazo A B
Human Reproductive Biology Unit, Soliman Fakeeh Hospital, Jeedah, Saudi Arabia.
Fertil Steril. 1991 Feb;55(2):328-32. doi: 10.1016/s0015-0282(16)54125-9.
The effect of induction of preovulatory endogenous surge of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) with intranasal administration of GnRH-analog (GnRH-a) in an in vitro fertilization (IVF) program is reported. The use of GnRH-a resulted in a significantly better percentage of replaceable embryos (91% versus 85%). The pregnancy rate was 51% in comparison with 32% in control cycles in which follicular maturation was achieved by human chorionic gonadotropin administration. There was no significant difference in the postoocyte recovery serum progesterone patterns between the two groups. Our results indicate that the induction of endogenous LH and FSH surge with GnRH-a may be successfully employed for final follicular maturation after ovarian suprastimulation without affecting the outcome of IVF adversely. Apart from being a more physiological approach to oocyte maturation, it also has potential economic and clinical advantages.
本文报道了在体外受精（IVF）程序中，经鼻给予促性腺激素释放激素类似物（GnRH-a）诱导促黄体生成素（LH）和促卵泡生成素（FSH）排卵前内源性高峰的效果。使用GnRH-a后，可移植胚胎的百分比显著提高（91%对85%）。妊娠率为51%，而通过注射人绒毛膜促性腺激素实现卵泡成熟的对照周期妊娠率为32%。两组在取卵后血清孕酮模式上无显著差异。我们的结果表明，使用GnRH-a诱导内源性LH和FSH高峰可成功用于卵巢超刺激后的最终卵泡成熟，且不会对IVF结果产生不利影响。除了是一种更符合生理的卵母细胞成熟方法外，它还具有潜在的经济和临床优势。
