waltzer突变体中存在微绒毛间连接表明Cdh23对于顶连接的形成并非必不可少。
Presence of interstereocilial links in waltzer mutants suggests Cdh23 is not essential for tip link formation.
作者信息
Rzadzinska A K, Steel K P
机构信息
Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, United Kingdom.
出版信息
Neuroscience. 2009 Jan 23;158(2):365-8. doi: 10.1016/j.neuroscience.2008.10.012. Epub 2008 Oct 17.
Cadherin23 has been proposed to form the upper part of the tip link, an interstereocilial link believed to control opening of transducer channels of sensory hair cells. However, we detect tip link-like links in mouse mutants with null alleles of Cdh23, suggesting the presence of other components that permit formation of a link between the tip of one stereocilium and the side of the adjacent taller stereocilium.
有人提出，钙黏蛋白23构成了顶连接的上部，顶连接是一种位于静纤毛之间的连接，被认为控制着感觉毛细胞换能通道的开放。然而，我们在Cdh23基因敲除的小鼠突变体中检测到了类似顶连接的连接，这表明存在其他成分，能够使一个静纤毛的顶端与相邻较高静纤毛的侧面形成连接。
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