Kamitakahara Masanobu, Ohtsuki Chikara, Miyazaki Toshiki
Graduate School of Environmental Studies, Tohoku University 6-6-20, Aoba, Aramaki, Aoba-ku, Sendai 980-8579, Japan.
J Biomater Appl. 2008 Nov;23(3):197-212. doi: 10.1177/0885328208096798.
Various calcium phosphates are used for bone repair. Although hydroxyapatite (HA) sintered ceramics are widely used due to their osteoconductivity, its bioresorbability is so low that HA remains in the body for a long time after implantation. In contrast, tricalcium phosphate (TCP) ceramics show resorbable characters during bone regeneration, and can be completely substituted for the bone tissue after stimulation of bone formation. Therefore, much attention is paid to TCP ceramics for scaffold materials for supporting bone regeneration. This paper reviews bioresorbable properties of calcium phosphate ceramics derived from beta-TCP and alpha-TCP.
各种磷酸钙被用于骨修复。尽管羟基磷灰石(HA)烧结陶瓷因其骨传导性而被广泛使用,但其生物可吸收性很低,以至于植入后HA会在体内长时间留存。相比之下,磷酸三钙(TCP)陶瓷在骨再生过程中表现出可吸收特性,并且在刺激骨形成后可以被骨组织完全替代。因此,TCP陶瓷作为支持骨再生的支架材料备受关注。本文综述了源自β-TCP和α-TCP的磷酸钙陶瓷的生物可吸收特性。