一种铂（II）金属嵌入剂的体内研究。
In vivo studies of a platinum(II) metallointercalator.
作者信息
Fisher Dianne M, Fenton Ronald R, Aldrich-Wright Janice R
机构信息
School of Chemistry, The University of Sydney, NSW 2006, Australia.
出版信息
Chem Commun (Camb). 2008 Nov 21(43):5613-5. doi: 10.1039/b811723c. Epub 2008 Sep 26.
DOI:10.1039/b811723c
PMID:18997969
Abstract
An in vivo study for determining the toxicity and efficacy of [Pt(S,S-dach)(phen)Cl(2).1.5H(2)O.0.5HCl (PHENSS) in female Specific Pathogen Free (SPF) Swiss nude mice bearing PC3 tumour xenografts revealed PHENSS to be non-toxic and effective in decreasing tumour growth.
摘要
一项关于测定[Pt(S,S-二氨基环己烷)(邻菲罗啉)氯(2).1.5水(2)氧.0.5盐酸(PHENSS)]对携带PC3肿瘤异种移植的雌性无特定病原体(SPF)瑞士裸鼠的毒性和疗效的体内研究表明，PHENSS无毒且能有效抑制肿瘤生长。
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