Hughes C S, Irvin C G, Rockwell S
Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06510.
Cancer Commun. 1991 Feb;3(2):29-35.
A wild type Chinese hamster cell line (AA8) and three repair-deficient sublines of AA8 (EM9, UV4, and UV5) were used to study the nature of the cytotoxic lesions produced by the bioreductive alkylating agents mitomycin C and porfiromycin under aerobic and hypoxic conditions. The sensitivities of the repair-deficient sublines to the drugs varied markedly: EM9 was similar to AA8, whereas UV4 was exquisitely sensitive and UV5 was of intermediate sensitivity. Moreover, both the relative toxicities of the two drugs and the relative toxicities of each drug under aerobic and hypoxic conditions varied for the different cell lines. These data suggest that there are differences in the spectra of toxic lesions produced by mitomycin and porfiromycin and that there are differences in the lesions produced by these drugs under aerobic and hypoxic conditions.
使用一种野生型中国仓鼠细胞系（AA8）以及AA8的三个修复缺陷亚系（EM9、UV4和UV5）来研究在需氧和缺氧条件下生物还原烷基化剂丝裂霉素C和卟吩姆钠产生的细胞毒性损伤的性质。修复缺陷亚系对这些药物的敏感性差异显著：EM9与AA8相似，而UV4极其敏感，UV5则具有中等敏感性。此外，两种药物的相对毒性以及每种药物在需氧和缺氧条件下的相对毒性在不同细胞系中也有所不同。这些数据表明，丝裂霉素和卟吩姆钠产生的毒性损伤谱存在差异，并且这些药物在需氧和缺氧条件下产生的损伤也存在差异。
