Haidari Fatemeh, Rashidi Mohammad R, Eshraghian Mohammad R, Mahboob Soltan A, Shahi Majid M, Keshavarz Seid A
School of Health and Institute of Public Health Research, Tehran University of Medical Sciences, Tehran, Iran.
Saudi Med J. 2008 Nov;29(11):1573-9.
To evaluate the hypouricemic and antioxidant effects of Allium cepa Lilliaceae (Allium cepa L.) and quercetin in normal and hyperuricemic rats.
The following study was conducted in the Department of Nutrition and Biochemistry, Tehran University of Medical Science, Iran, between May 2007 and March 2008. A total of 48 male Wistar rats (body weights: 180-200 g) were randomly divided into 8 equal groups including normal; normal + Allium cepa L. (5g/kg); normal + quercetin (5mg/kg); normal + allopurinol (5mg/kg); hyperuricemic; hyperuricemic + Allium cepa L. (5g/kg); hyperuricemic + quercetin (5mg/kg); hyperuricemic + allopurinol (5mg/kg) once a day for 14 days. Experimentally, hyperuricemia in rats was induced by intraperitoneal injection of potassium oxonate (250mg/kg).
Allium cepa L. and quercetin treatments for 14 days significantly reduced (p=0.000) the serum uric acid levels of hyperuricemic rats in a time-dependent manner. All treatments significantly inhibited hepatic xanthine oxidase/xanthine dehydrogenase activity. Allium cepa L. and quercetin treatments led also to a significant improvement in biomarkers of oxidative stress in hyperuricemic rats (p=0.000). Although the hypouricemic effect of allopurinol was much higher than that of Allium cepa L. and quercetin, it could not significantly change oxidative stress biomarkers.
These results may be responsible partly for the beneficial effects of Allium cepa L. and its major flavonoid on hyperuricemia and oxidative stress.
评估葱属植物（葱）和槲皮素对正常及高尿酸血症大鼠的降尿酸和抗氧化作用。
2007年5月至2008年3月，在伊朗德黑兰医科大学营养与生物化学系进行了以下研究。将48只雄性Wistar大鼠（体重：180 - 200克）随机分为8组，每组数量相等，包括正常组；正常 + 葱（5克/千克）组；正常 + 槲皮素（5毫克/千克）组；正常 + 别嘌醇（5毫克/千克）组；高尿酸血症组；高尿酸血症 + 葱（5克/千克）组；高尿酸血症 + 槲皮素（5毫克/千克）组；高尿酸血症 + 别嘌醇（5毫克/千克）组，每天给药一次，持续14天。实验中，通过腹腔注射氧嗪酸钾（250毫克/千克）诱导大鼠高尿酸血症。
葱和槲皮素治疗14天可显著降低（p = 0.000）高尿酸血症大鼠的血清尿酸水平，且呈时间依赖性。所有治疗均显著抑制肝脏黄嘌呤氧化酶/黄嘌呤脱氢酶活性。葱和槲皮素治疗还使高尿酸血症大鼠的氧化应激生物标志物有显著改善（p = 0.000）。虽然别嘌醇的降尿酸作用远高于葱和槲皮素，但它不能显著改变氧化应激生物标志物。
这些结果可能部分解释了葱及其主要黄酮类化合物对高尿酸血症和氧化应激的有益作用。
